Study of GABA in healthy volunteers: pharmacokinetics and pharmacodynamics

• Main Authors: Junfeng eLi (Author), Zhaoyun eZhang (Author), Xiaoxia eLiu (Author), Yi eWang (Author), Fei eMao (Author), Junjun eMao (Author), Xiaolan eLu (Author), Dongdong eJiang (Author), Yun eWan (Author), Jia-Ying eLv (Author), Guoying eCao (Author), Qing eZhang (Author), Naiqing eZhao (Author), Mark eAtkinson (Author), Dale L. Greiner (Author), Gerald J. Prud'homme (Author), Zheng eJiao (Author), Yiming eLi (Author), Qinghua eWang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Preclinical studies show that GABA exerts anti-diabetic effects in rodent models of type 1 diabetes. Because little is known about its absorption and effects in humans, we investigated the pharmacokinetics and pharmacodynamics of GABA in healthy volunteers. Twelve subjects were subjected to an open-...