New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies

• Main Authors: Hazem Elkady (Author), Alaa Elwan (Author), Hesham A. El-Mahdy (Author), Ahmed S. Doghish (Author), Ahmed Ismail (Author), Mohammed S. Taghour (Author), Eslam B. Elkaeed (Author), Ibrahim H. Eissa (Author), Mohammed A. Dahab (Author), Hazem A. Mahdy (Author), Mohamed M. Khalifa (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of benzoxazole derivatives were designed and synthesised to have the main essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were evaluated for all derivatives against two human cancer cell lines, MCF-7 and HepG2. Also, the effect of the most cytotoxic derivat...