Low-Affinity NMDA Receptor Antagonist Hemantane in a Topical Formulation Attenuates Arthritis Induced by Freund's Complete Adjuvant in Rats

• Main Authors: Elena Ivanova (Author), Alexander Matyushkin (Author), Alexandra Sorokina (Author), Svetlana Alexeeva (Author), Irina Miroshkina (Author), Kirill Kachalov (Author), Tatyana Voronina (Author), Andrey Durnev (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: N-methyl-D-aspartate (NMDA) receptors that are expressed by T-cells modulate T-cell proliferation, cytotoxicity and cell migration toward chemokines. Several studies have shown an anti-inflammatory effect of NMDA receptor antagonists. This study compares the effect of the noncompetitive low...