Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease

• Main Authors: Nahed Khadhraoui (Author), Alexandre Prola (Author), Aymeline Vandestienne (Author), Jordan Blondelle (Author), Laurent Guillaud (Author), Guillaume Courtin (Author), Maxime Bodak (Author), Bastien Prost (Author), Hélène Huet (Author), Mélody Wintrebert (Author), Christine Péchoux (Author), Audrey Solgadi (Author), Frédéric Relaix (Author), Laurent Tiret (Author), Fanny Pilot-Storck (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Mitochondria fuel most animal cells with ATP, ensuring proper energetic metabolism of organs. Early and extensive mitochondrial dysfunction often leads to severe disorders through multiorgan failure. Hacd2 gene encodes an enzyme involved in very long chain fatty acid (C ≥ 18) synthesis, y...