Association of Single-Nucleotide Polymorphisms in Capecitabine Bioactivation Pathway with Adjuvant Therapy Safety in Colorectal Cancer Patients

• Main Authors: Yasmin Cura (Author), Almudena Sánchez-Martín (Author), Noelia Márquez-Pete (Author), Encarnación González-Flores (Author), Fernando Martínez-Martínez (Author), Cristina Pérez-Ramírez (Author), Alberto Jiménez-Morales (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Capecitabine, an oral prodrug of 5-fluorouracil (5-FU), is part of the standard treatment of colorectal cancer (CRC). Severe adverse dose limiting reactions that impair treatment safety and lead to treatment suspension remain a relevant concern. Single-nucleotide polymorphisms (SNPs) in genes involv...