Association of Single-Nucleotide Polymorphisms in Capecitabine Bioactivation Pathway with Adjuvant Therapy Safety in Colorectal Cancer Patients

• 主要な著者: Yasmin Cura (著者), Almudena Sánchez-Martín (著者), Noelia Márquez-Pete (著者), Encarnación González-Flores (著者), Fernando Martínez-Martínez (著者), Cristina Pérez-Ramírez (著者), Alberto Jiménez-Morales (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2023-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Capecitabine, an oral prodrug of 5-fluorouracil (5-FU), is part of the standard treatment of colorectal cancer (CRC). Severe adverse dose limiting reactions that impair treatment safety and lead to treatment suspension remain a relevant concern. Single-nucleotide polymorphisms (SNPs) in genes involv...