Study of Linearization of Hill Dose-Effect Curve with Metabolic Velocity Instead of Drug Concentration

• Main Authors: Run-Nan LIU (Author), Yu TANG (Author), Ping-An LIU (Author), Wen-Long LIU (Author), Qi-Meng FAN (Author), Si-Yang CHEN (Author), Peng HE (Author), Hai-Ying LI (Author), Fu-Yuan HE (Author), Kai-Wen DENG (Author)
• Format: Book
• Published: KeAi Communications Co., Ltd., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT: Objective To explore the velocity-effect relationship in order to the establish linearization of effect on an equation with regard to the consistency of the Hill dose-effect expression with the metabolic kinetics of receptors.Methods The linear velocity-effect expression was obtained by so...