Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1

• Main Authors: Nicklas Heine Staunstrup (Author), Karin Stenderup (Author), Sidsel Mortensen (Author), Maria Nascimento Primo (Author), Cecilia Rosada (Author), Torben Steiniche (Author), Ying Liu (Author), Rong Li (Author), Mette Schmidt (Author), Stig Purup (Author), Frederik Dagnæs-Hansen (Author), Lisbeth Dahl Schrøder (Author), Lars Svensson (Author), Thomas Kongstad Petersen (Author), Henrik Callesen (Author), Lars Bolund (Author), Jacob Giehm Mikkelsen (Author)
• Format: Book
• Published: The Company of Biologists, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Psoriasis is a complex human-specific disease characterized by perturbed keratinocyte proliferation and a pro-inflammatory environment in the skin. Porcine skin architecture and immunity are very similar to that in humans, rendering the pig a suitable animal model for studying the biology and treatm...