Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models

• Main Authors: Ryusuke Sugita (Author), Harumi Kuwabara (Author), Kazufumi Kubota (Author), Kotaro Sugimoto (Author), Toshihiro Kiho (Author), Atsushi Tengeiji (Author), Katsuhiro Kawakami (Author), Kohei Shimada (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prostaglandin E2 (PGE2) is well known as a mediator of inflammatory symptoms such as fever, arthritis, and inflammatory pain. In the present study, we evaluated the analgesic effect of our selective PGE2 synthesis inhibitor, compound I, 2-methyl-2-[cis-4-([1-(6-methyl-3-phenylquinolin-2-yl)piperidin...