Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models

• 主要な著者: Ryusuke Sugita (著者), Harumi Kuwabara (著者), Kazufumi Kubota (著者), Kotaro Sugimoto (著者), Toshihiro Kiho (著者), Atsushi Tengeiji (著者), Katsuhiro Kawakami (著者), Kohei Shimada (著者)
• フォーマット: 図書
• 出版事項: Hindawi Limited, 2016-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Prostaglandin E2 (PGE2) is well known as a mediator of inflammatory symptoms such as fever, arthritis, and inflammatory pain. In the present study, we evaluated the analgesic effect of our selective PGE2 synthesis inhibitor, compound I, 2-methyl-2-[cis-4-([1-(6-methyl-3-phenylquinolin-2-yl)piperidin...