Stimulation of peripheral Kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway

• Main Authors: Cunha Thiago M (Author), Souza Guilherme R (Author), Domingues Andressa C (Author), Carreira Eleonora U (Author), Lotufo Celina M (Author), Funez Mani I (Author), Verri Waldiceu A (Author), Cunha Fernando Q (Author), Ferreira Sergio H (Author)
• Format: Book
• Published: SAGE Publishing, 2012-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>In addition to their central effects, opioids cause peripheral analgesia. There is evidence showing that peripheral activation of kappa opioid receptors (KORs) inhibits inflammatory pain. Moreover, peripheral μ-opioid receptor (MOR)...