Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation

• Main Authors: So-Hyeon Park (Author), Yunkyung Heo (Author), Il Kwon (Author), Sungwoo Jo (Author), Hyejin Jeon (Author), Yechan Lee (Author), Jieun Kim (Author), Ji Hoe Heo (Author), Wan Namkung (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Protease-activated receptor 1 (PAR1) is expressed in human platelets and can be activated by low concentrations of thrombin. Vorapaxar, a selective antagonist of PAR1, inhibits thrombin-induced calcium mobilization in human platelet, which is associated with an increased risk of bleeding...