A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin, a novel recombinant anticoagulant protein, in healthy subjects

• Main Authors: Yubin Liu (Author), Meixia Wang (Author), Xiaona Dong (Author), Jia He (Author), Lin Zhang (Author), Ying Zhou (Author), Xia Xia (Author), Guifang Dou (Author), Chu‐tse Wu (Author), Jide Jin (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The aim of this study was to evaluate the tolerability, safety, and pharmacokinetics of single and continuous dose administration of recombinant neorudin (EPR‐hirudin, EH) by intravenous administration in healthy subjects, and to provide a safe dosage range for phase II clinical research. F...