Fungal pyrrolidine-containing metabolites inhibit alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblastoma cells

• Main Authors: Takashi Fukuda (Author), Ryuji Uchida (Author), Hiroyo Inoue (Author), Satoshi Ohte (Author), Hiroyuki Yamazaki (Author), Daisuke Matsuda (Author), Takenobu Katagiri (Author), Hiroshi Tomoda (Author)
• Format: Book
• Published: Elsevier, 2012-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant congenital disorder characterized by progressive heterotopic ossification in muscle tissues. A constitutively activated mutation of a bone morphogenetic protein (BMP) receptor, ALK2, has been identified in patients with FOP. We...