Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and fosters parasite virulence.

• Main Authors: Calvin A Henard (Author), Eric D Carlsen (Author), Christie Hay (Author), Peter E Kima (Author), Lynn Soong (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Professional phagocytes generate a myriad of antimicrobial molecules to kill invading microorganisms, of which nitrogen oxides are integral in controlling the obligate intracellular pathogen Leishmania. Although reactive nitrogen species produced by the inducible nitric oxide synthase (iNOS) can pro...