Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells

• Hauptverfasser: Emma J. Steer (Verfasst von), Zhaokang Yang (Verfasst von), Moza M. Al-Owais (Verfasst von), Hannah M. Kirton (Verfasst von), Edward White (Verfasst von), Derek S. Steele (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Background and purpose: While flecainide is now an accepted treatment for arrhythmias associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), its mechanism of action remains controversial. In studies on myocytes from CPVT mice, inhibition of proarrhythmic Ca2+ waves was initial...