Delivering bioactive cyclic peptides that target Hsp90 as prodrugs

• Main Authors: Yuantao Huo (Author), Laura K. Buckton (Author), Jack L. Bennett (Author), Eloise C. Smith (Author), Frances L. Byrne (Author), Kyle L. Hoehn (Author), Marwa N. Rahimi (Author), Shelli R. McAlpine (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The most challenging issue facing peptide drug development is producing a molecule with optimal physical properties while maintaining target binding affinity. Masking peptides with protecting groups that can be removed inside the cell, produces a cell-permeable peptide, which theoretically can maint...