Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery

• Main Authors: Magdalena M. Żak (Author), Keerat Kaur (Author), Jimeen Yoo (Author), Ann Anu Kurian (Author), Matthew Adjmi (Author), Gayatri Mainkar (Author), Seonghun Yoon (Author), Lior Zangi (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Directly injecting naked or lipid nanoparticle (LNP)-encapsulated modified mRNA (modRNA) allows rapid and efficient protein expression. This non-viral technology has been used successfully in modRNA vaccines against SARS-CoV-2. The main challenges in using modRNA vaccines were the initial requiremen...