Optimization of 2-Aminoquinazolin-4-(3<i>H</i>)-one Derivatives as Potent Inhibitors of SARS-CoV-2: Improved Synthesis and Pharmacokinetic Properties
We previously reported the potent antiviral effect of the 2-aminoquinazolin-4-(3<i>H</i>)-one <b>1</b>, which shows significant activity (IC<sub>50</sub> = 0.23 μM) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with no cytotoxicity. However,...
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MDPI AG,
2022-07-01T00:00:00Z.
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