Optimization of 2-Aminoquinazolin-4-(3<i>H</i>)-one Derivatives as Potent Inhibitors of SARS-CoV-2: Improved Synthesis and Pharmacokinetic Properties

• Main Authors: Young Sup Shin (Author), Jun Young Lee (Author), Sangeun Jeon (Author), Jung-Eun Cho (Author), Subeen Myung (Author), Min Seong Jang (Author), Seungtaek Kim (Author), Jong Hwan Song (Author), Hyoung Rae Kim (Author), Hyeung-geun Park (Author), Lak Shin Jeong (Author), Chul Min Park (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously reported the potent antiviral effect of the 2-aminoquinazolin-4-(3<i>H</i>)-one <b>1</b>, which shows significant activity (IC₅₀ = 0.23 μM) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with no cytotoxicity. However,...