Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease

• Những tác giả chính: Anisha K. Nigam (Tác giả), Anupam A. Ojha (Tác giả), Julia G. Li (Tác giả), Da Shi (Tác giả), Vibha Bhatnagar (Tác giả), Kabir B. Nigam (Tác giả), Ruben Abagyan (Tác giả), Sanjay K. Nigam (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2021-10-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

In patients with liver or kidney disease, it is especially important to consider the routes of metabolism and elimination of small-molecule pharmaceuticals. Once in the blood, numerous drugs are taken up by the liver for metabolism and/or biliary elimination, or by the kidney for renal elimination....