Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease

• Asıl Yazarlar: Anisha K. Nigam (Yazar), Anupam A. Ojha (Yazar), Julia G. Li (Yazar), Da Shi (Yazar), Vibha Bhatnagar (Yazar), Kabir B. Nigam (Yazar), Ruben Abagyan (Yazar), Sanjay K. Nigam (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2021-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

In patients with liver or kidney disease, it is especially important to consider the routes of metabolism and elimination of small-molecule pharmaceuticals. Once in the blood, numerous drugs are taken up by the liver for metabolism and/or biliary elimination, or by the kidney for renal elimination....