Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease

• Auteurs principaux: Anisha K. Nigam (Auteur), Anupam A. Ojha (Auteur), Julia G. Li (Auteur), Da Shi (Auteur), Vibha Bhatnagar (Auteur), Kabir B. Nigam (Auteur), Ruben Abagyan (Auteur), Sanjay K. Nigam (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

In patients with liver or kidney disease, it is especially important to consider the routes of metabolism and elimination of small-molecule pharmaceuticals. Once in the blood, numerous drugs are taken up by the liver for metabolism and/or biliary elimination, or by the kidney for renal elimination....