Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease

Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease

In patients with liver or kidney disease, it is especially important to consider the routes of metabolism and elimination of small-molecule pharmaceuticals. Once in the blood, numerous drugs are taken up by the liver for metabolism and/or biliary elimination, or by the kidney for renal elimination....

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Main Authors: Anisha K. Nigam (Author), Anupam A. Ojha (Author), Julia G. Li (Author), Da Shi (Author), Vibha Bhatnagar (Author), Kabir B. Nigam (Author), Ruben Abagyan (Author), Sanjay K. Nigam (Author)
Format: Book
Published: MDPI AG, 2021-10-01T00:00:00Z.
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