Effect of Extracellular Matrix Stiffness on Candesartan Efficacy in Anti-Fibrosis and Antioxidation

• Main Authors: Tong Zhu (Author), Jingjing Song (Author), Bin Gao (Author), Junjie Zhang (Author), Yabei Li (Author), Zhaoyang Ye (Author), Yuxiang Zhao (Author), Xiaogang Guo (Author), Feng Xu (Author), Fei Li (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myocardial fibrosis progression and imbalanced redox state are closely associated with increased extracellular matrix (ECM) stiffness. Candesartan (CAN), an angiotensin II (Ang II) receptor inhibitor, has shown promising anti-fibrosis and antioxidant efficacy in previous cardiovascular disease studi...