Protective immune responses against Schistosoma mansoni infection by immunization with functionally active gut-derived cysteine peptidases alone and in combination with glyceraldehyde 3-phosphate dehydrogenase.

• Main Authors: Hatem Tallima (Author), Jan Dvořák (Author), Sahira Kareem (Author), Marwa Abou El Dahab (Author), Nada Abdel Aziz (Author), John Pius Dalton (Author), Rashika El Ridi (Author)
• Format: Bog
• Udgivet: Public Library of Science (PLoS), 2017-03-01T00:00:00Z.
• Fag: article
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BACKGROUND:Schistosomiasis, a severe disease caused by parasites of the genus Schistosoma, is prevalent in 74 countries, affecting more than 250 million people, particularly children. We have previously shown that the Schistosoma mansoni gut-derived cysteine peptidase, cathepsin B1 (SmCB1), administ...