Population Pharmacodynamic Model of Neutrophil Margination and Tolerance to Describe Effect of Sarilumab on Absolute Neutrophil Count in Patients with Rheumatoid Arthritis

• Main Authors: Pavel Kovalenko (Author), Anne Paccaly (Author), Anita Boyapati (Author), Christine Xu (Author), Gregory St John (Author), Michael C. Nivens (Author), John D. Davis (Author), Ronda Rippley (Author), A. Thomas DiCioccio (Author)
• Format: Book
• Published: Wiley, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Evidence suggests that effects of interleukin‐6 pathway inhibitors sarilumab, tocilizumab, and sirukumab on absolute neutrophil count (ANC) are due to margination of circulating neutrophils into rapidly mobilizable noncirculating pools. We developed a population pharmacodynamic model using compartme...