Pharmacological inhibition of lipolysis prevents adverse metabolic outcomes during glucocorticoid administration

• Main Authors: Melissa A. Linden (Author), Susan J. Burke (Author), Humza A. Pirzadah (Author), Tai-Yu Huang (Author), Heidi M. Batdorf (Author), Walid K. Mohammed (Author), Katarina A. Jones (Author), Sujoy Ghosh (Author), Shawn R. Campagna (Author), J. Jason Collier (Author), Robert C. Noland (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucocorticoids are one of the most commonly prescribed classes of anti-inflammatory drugs; however, chronic treatment promotes iatrogenic (drug-induced) diabetes. As part of their physiological role, glucocorticoids stimulate lipolysis to spare glucose. We hypothesized that persistent st...