Low aerobic capacity in McArdle disease: A role for mitochondrial network impairment?

• Main Authors: M. Villarreal-Salazar (Author), A. Santalla (Author), A. Real-Martínez (Author), G. Nogales-Gadea (Author), P.L. Valenzuela (Author), C. Fiuza-Luces (Author), A.L. Andreu (Author), J.C. Rodríguez-Aguilera (Author), M.A. Martín (Author), J. Arenas (Author), J. Vissing (Author), A. Lucia (Author), T.O. Krag (Author), T. Pinós (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: McArdle disease is caused by myophosphorylase deficiency and results in complete inability for muscle glycogen breakdown. A hallmark of this condition is muscle oxidation impairment (e.g., low peak oxygen uptake (VO2peak)), a phenomenon traditionally attributed to reduced glycolytic flux...