Clinical Trial: CYP2D6 Related Dose Escalation of Tamoxifen in Breast Cancer Patients With Iranian Ethnic Background Resulted in Increased Concentrations of Tamoxifen and Its Metabolites

• मुख्य लेखकों: Zahra Khalaj (लेखक), Zohreh Baratieh (लेखक), Parvaneh Nikpour (लेखक), Matthias Schwab (लेखक), Elke Schaeffeler (लेखक), Fariborz Mokarian (लेखक), Hossein Khanahmad (लेखक), Rasoul Salehi (लेखक), Thomas E. Mürdter (लेखक), Mansoor Salehi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Introduction: The polymorphic enzyme cytochrome P450 2D6 (CYP2D6) catalyzes a major step in the bioactivation of tamoxifen. Genotyping of clinically relevant CYP2D6 alleles and subsequent dose adjustment is a promising approach to individualize breast cancer therapy. The aim of this study was to inv...