Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis

• المؤلفون الرئيسيون: Jiraphorn Issara-Amphorn (مؤلف), Wiwat Chancharoenthana (مؤلف), Peerapat Visitchanakun (مؤلف), Asada Leelahavanichkul (مؤلف)
• التنسيق: كتاب
• منشور في: Karger Publishers, 2020-09-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (F...