Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma

• Main Authors: Youming Zhang (Author), Thanushiyan Poobalasingam (Author), Laura L. Yates (Author), Simone A. Walker (Author), Martin S. Taylor (Author), Lauren Chessum (Author), Jackie Harrison (Author), Loukia Tsaprouni (Author), Ian M. Adcock (Author), Clare M. Lloyd (Author), William O. Cookson (Author), Miriam F. Moffatt (Author), Charlotte H. Dean (Author)
• Format: Book
• Published: The Company of Biologists, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously identified dipeptidylpeptidase 10 (DPP10) on chromosome 2 as a human asthma susceptibility gene, through positional cloning. Initial association results were confirmed in many subsequent association studies but the functional role of DPP10 in asthma remains unclear. Using the MRC Harwe...