Diethylalkylsulfonamido(4-methoxyphenyl)methyl)phosphonate/phosphonic acid derivatives act as acid phosphatase inhibitors: synthesis accompanied by experimental and molecular modeling assessments

• Main Authors: Nahid Alimoradi (Author), Mohammad Reza Ashrafi-Kooshk (Author), Mohsen Shahlaei (Author), Shabnam Maghsoudi (Author), Hadi Adibi (Author), Ross P. McGeary (Author), Reza Khodarahmi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purple acid phosphatases (PAPs) are binuclear metallo-hydrolases that have been isolated from various mammals, plants, fungi and bacteria. In mammals, PAP activity is associated with bone resorption and can lead to bone metabolic disorders such as osteoporosis; thus human PAP is an attractive target...