Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel

• Main Authors: Marco Vinicius Chaud (Author), Pollyanna Tamascia (Author), Andréa Cristina de Lima (Author), Maria Ondina Paganelli (Author), Maria Palmira Daflon Gremião (Author), Osvaldo de Freitas (Author)
• Format: Book
• Published: Universidade de São Paulo, 2010-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first drug of choice in the treatment of schistosomiasis, its poor solubility has...