Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel

• Hauptverfasser: Marco Vinicius Chaud (Verfasst von), Pollyanna Tamascia (Verfasst von), Andréa Cristina de Lima (Verfasst von), Maria Ondina Paganelli (Verfasst von), Maria Palmira Daflon Gremião (Verfasst von), Osvaldo de Freitas (Verfasst von)
• Format: Buch
• Veröffentlicht: Universidade de São Paulo, 2010-09-01T00:00:00Z.
• Schlagworte: article
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The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first drug of choice in the treatment of schistosomiasis, its poor solubility has...