Susceptibility to Ventricular Arrhythmias Resulting from Mutations in FKBP1B, PXDNL, and SCN9A Evaluated in hiPSC Cardiomyocytes

• Главные авторы: Hector Barajas-Martinez (Автор), Maya Smith (Автор), Dan Hu (Автор), Robert J. Goodrow (Автор), Colleen Puleo (Автор), Can Hasdemir (Автор), Charles Antzelevitch (Автор), Ryan Pfeiffer (Автор), Jacqueline A. Treat (Автор), Jonathan M. Cordeiro (Автор)
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• Опубликовано: Hindawi Limited, 2020-01-01T00:00:00Z.
• Предметы: article
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Background. We report an inherited cardiac arrhythmia syndrome consisting of Brugada and Early Repolarization Syndrome associated with variants in SCN9A, PXDNL, and FKBP1B. The proband inherited the 3 mutations and exhibited palpitations and arrhythmia-mediated syncope, whereas the parents and siste...