Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5'-Triphosphate in the Rat

• Main Authors: Megumi Sugihara (Author), Hiromitsu Morita (Author), Miho Matsuda (Author), Hisanori Umebayashi (Author), Shunichi Kajioka (Author), Shinichi Ito (Author), Motohiro Nishida (Author), Ryosuke Inoue (Author), Toshiko Futatsuki (Author), Jun Yamazaki (Author), Yasuo Mori (Author), Ryuji Inoue (Author), Yushi Ito (Author), Kihachiro Abe (Author), Masato Hirata (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated actions of uridine 5'-triphosphate (UTP) in rat aorta, cerebral and mesenteric arteries, and their single myocytes. UTP (≥10 μM) elicited an inward-rectifying current strongly reminiscent of activation of P2X1 receptor, and a similar current was also induced by α,β-methylene ade...