Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women
Abstract Optimal dosing in pregnant and lactating women requires an understanding of the pharmacokinetics in the mother, fetus, and breastfed infant. Physiologically‐based pharmacokinetic (PBPK) modeling can be used to simulate untested scenarios and hence supplement clinical data to support dosing...
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Wiley,
2024-11-01T00:00:00Z.
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