Antimicrobial Peptides Designed against the Ω-Loop of Class A β-Lactamases to Potentiate the Efficacy of β-Lactam Antibiotics

• Main Authors: Sarmistha Biswal (Author), Karina Caetano (Author), Diamond Jain (Author), Anusha Sarrila (Author), Tulika Munshi (Author), Rachael Dickman (Author), Alethea B. Tabor (Author), Surya Narayan Rath (Author), Sanjib Bhakta (Author), Anindya S. Ghosh (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Class A serine β-lactamases (SBLs) have a conserved non-active site structural domain called the omega loop (Ω-loop), in which a glutamic acid residue is believed to be directly involved in the hydrolysis of β-lactam antibiotics by providing a water molecule during catalysis. We aimed to design and...