Establishment and Evaluation of a Parametric Population Pharmacokinetic Model Repository for Ganciclovir and Valganciclovir

• Main Authors: Wenyu Yang (Author), Wenyao Mak (Author), Amanda Gwee (Author), Meng Gu (Author), Yue Wu (Author), Yufei Shi (Author), Qingfeng He (Author), Xiaoqiang Xiang (Author), Bing Han (Author), Xiao Zhu (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Ganciclovir and valganciclovir are used for prophylaxis and treatment of cytomegalovirus infection. However, there is great interindividual variability in ganciclovir's pharmacokinetics (PK), highlighting the importance of individualized dosing. To facilitate model-informed precisio...