Establishment and Evaluation of a Parametric Population Pharmacokinetic Model Repository for Ganciclovir and Valganciclovir

• Автори: Wenyu Yang (Автор), Wenyao Mak (Автор), Amanda Gwee (Автор), Meng Gu (Автор), Yue Wu (Автор), Yufei Shi (Автор), Qingfeng He (Автор), Xiaoqiang Xiang (Автор), Bing Han (Автор), Xiao Zhu (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2023-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Background: Ganciclovir and valganciclovir are used for prophylaxis and treatment of cytomegalovirus infection. However, there is great interindividual variability in ganciclovir's pharmacokinetics (PK), highlighting the importance of individualized dosing. To facilitate model-informed precisio...