Valproic Acid Induces Endothelial-to-Mesenchymal Transition-Like Phenotypic Switching

• Autors principals: Shamini Murugavel (Autor), Antoinette Bugyei-Twum (Autor), Pratiek N. Matkar (Autor), Husain Al-Mubarak (Autor), Hao H. Chen (Autor), Mohamed Adam (Autor), Shubha Jain (Autor), Tanya Narang (Autor), Rawand M. Abdin (Autor), Mohammad Qadura (Autor), Kim A. Connelly (Autor), Howard Leong-Poi (Autor), Krishna K. Singh (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is a widely used anticonvulsant drug that is currently undergoing clinical evaluation for anticancer therapy due to its anti-angiogenic potential. Endothelial cells (ECs) can transition into mesenchymal cells and this form of EC plasticity...