Differential Effects of Cytokine Versus Hypoxic Preconditioning of Human Mesenchymal Stromal Cells in Pulmonary Sepsis Induced by Antimicrobial-Resistant <i>Klebsiella pneumoniae</i>

• Main Authors: Declan Byrnes (Author), Claire H. Masterson (Author), Jack Brady (Author), Senthilkumar Alagesan (Author), Hector E. Gonzalez (Author), Sean D. McCarthy (Author), Juan Fandiño (Author), Daniel P. O'Toole (Author), John G. Laffey (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background</b>: Pulmonary sepsis is a leading cause of hospital mortality, and sepses arising from antimicrobial-resistant (AMR) bacterial strains are particularly difficult to treat. Here we investigated the potential of mesenchymal stromal cells (MSCs) to combat established <i>...