Anti-apoptotic and Hepatoprotective Effects of Gomisin A on Fulminant Hepatic Failure Induced by D-Galactosamine and Lipopolysaccharide in Mice

• Main Authors: Sung-Hwa Kim (Author), Yeong Shik Kim (Author), Sam Sik Kang (Author), KiHwan Bae (Author), Tran Manh Hung (Author), Sun-Mee Lee (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study examined the effects of gomisin A, a lignan compound from Schisandra fructus, on D-galactosamine (GalN) and lipopolysaccharide (LPS)-induced hepatic apoptosis and liver failure. Mice were given an intraperitoneal injection of GalN (700 mg/kg) / LPS (10 μ g/kg). Gomisin A (25, 50, 100, and...