Analysis of Arrhythmogenic Profile in a Canine Model of Chronic Atrioventricular Block by Comparing In Vitro Effects of the Class III Antiarrhythmic Drug Nifekalant on the Ventricular Action Potential Indices Between Normal Heart and Atrioventricular Block Heart

• Main Authors: Akira Takahara (Author), Hideki Nakamura (Author), Hideaki Nouchi (Author), Takeshi Tamura (Author), Toshikazu Tanaka (Author), Hideaki Shimada (Author), Miku Tamura (Author), Noriko Tsuruoka (Author), Kentaro Takeda (Author), Hikaru Tanaka (Author), Koki Shigenobu (Author), Keitaro Hashimoto (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The chronic atrioventricular block dog is a useful model for predicting the future onset of drug-induced long QT syndrome in clinical practice. To better understand the arrhythmogenic profile of this model, we recorded the action potentials of the isolated ventricular tissues in the presence and abs...