Population pharmacokinetic analysis and dosing optimization of polymyxin B in critically ill patients

• Main Authors: Danhong Liang (Author), Zhi Liang (Author), Guoliang Deng (Author), Anfen Cen (Author), Dandan Luo (Author), Chen Zhang (Author), Suiqin Ni (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Since the global broadcast of multidrug-resistant gram-negative bacteria is accelerating, the use of Polymyxin B is sharply increasing, especially in critically ill patients. Unsatisfactory therapeutic effects were obtained because of the abnormal physiological function in critically ill...