Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.

• Main Authors: Martin S Llewellyn (Author), Louisa A Messenger (Author), Alejandro O Luquetti (Author), Lineth Garcia (Author), Faustino Torrico (Author), Suelene B N Tavares (Author), Bachar Cheaib (Author), Nicolas Derome (Author), Marc Delepine (Author), Céline Baulard (Author), Jean-Francois Deleuze (Author), Sascha Sauer (Author), Michael A Miles (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Chagas disease results from infection with the diploid protozoan parasite Trypanosoma cruzi. T. cruzi is highly genetically diverse, and multiclonal infections in individual hosts are common, but little studied. In this study, we explore T. cruzi infection multiclonality in the context of...