A Novel Role for Programmed Cell Death Receptor Ligand-1 in Sepsis-Induced Intestinal Dysfunction

• Main Authors: Youping Wu (Author), Chun-Shiang Chung (Author), Yaping Chen (Author), Sean Farrell Monaghan (Author), Sima Patel (Author), Xin Huang (Author), Daithi Seamus Heffernan (Author), Alfred Ayala (Author)
• Format: Book
• Published: BMC, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Studies imply that intestinal barrier dysfunction is a key contributor to morbid events associated with sepsis. Recently, the co-inhibitory molecule programmed death-ligand1 (PD-L1) has been shown to be involved in the regulation of intestinal immune tolerance and/or inflammation. Our previ...