NEDD4L in human tumors: regulatory mechanisms and dual effects on anti-tumor and pro-tumor

• Main Authors: Meng Zhang (Author), Zhenyong Zhang (Author), Xin Tian (Author), Enchong Zhang (Author), Yichun Wang (Author), Jun Tang (Author), Jianzhu Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumorigenesis and tumor development are closely related to the abnormal regulation of ubiquitination. Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L), an E3 ubiquitin ligase critical to the ubiquitination process, plays key roles in the regulation of cancer stem cells,...