Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes

• Main Authors: Angela Maria Cozzolino (Author), Valeria Noce (Author), Cecilia Battistelli (Author), Alessandra Marchetti (Author), Germana Grassi (Author), Carla Cicchini (Author), Marco Tripodi (Author), Laura Amicone (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In many cell types, several cellular processes, such as differentiation of stem/precursor cells, maintenance of differentiated phenotype, motility, adhesion, growth, and survival, strictly depend on the stiffness of extracellular matrix that, in vivo, characterizes their correspondent organ and tiss...