Population pharmacokinetics of valproic acid in children with epilepsy: Implications for dose tailoring when switching from oral syrup to sustained‐release tablets

• Main Authors: Wei‐Jun Wang (Author), Yue Li (Author), Ya‐Hui Hu (Author), Jie Wang (Author), Yuan‐Yuan Zhang (Author), Lin Fan (Author), Hao‐Ran Dai (Author), Hong‐Li Guo (Author), Xuan‐Sheng Ding (Author), Feng Chen (Author)
• Format: Book
• Published: Wiley, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Significant pharmacokinetic (PK) differences exist between different forms of valproic acid (VPA), such as syrup and sustained‐release (SR) tablets. This study aimed to develop a population pharmacokinetic (PopPK) model for VPA in children with epilepsy and offer dose adjustment recommendat...