Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone

• Main Authors: Bruno Tello Rubio (Author), Florence Bugault (Author), Blandine Baudon (Author), Bertrand Raynal (Author), Sébastien Brûlé (Author), Jean-David Morel (Author), Sarah Saint-Auret (Author), Nicolas Blanchard (Author), Caroline Demangel (Author), Laure Guenin-Macé (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative agent of Buruli ulcer disease. Altough bacterially derived mycolactone has been shown to traffic from cutaneous foci of infection to the bloodstream, the mechanisms underpinning its access to systemic circulati...