Soulamarin isolated from Calophyllum brasiliense (Clusiaceae) induces plasma membrane permeabilization of Trypanosoma cruzi and mytochondrial dysfunction.

• Main Authors: Alexandre Rea (Author), Andre G Tempone (Author), Erika G Pinto (Author), Juliana T Mesquita (Author), Eliana Rodrigues (Author), Luciana Grus M Silva (Author), Patricia Sartorelli (Author), João Henrique G Lago (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease is caused by the parasitic protozoan Trypanosoma cruzi. It has high mortality as well as morbidity rates and usually affects the poorer sections of the population. The development of new, less harmful and more effective drugs is a promising research target, since current standard trea...