Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach

• Main Authors: Katalin Prokai-Tatrai (Author), Daniel L. De La Cruz (Author), Vien Nguyen (Author), Benjamin P. Ross (Author), Istvan Toth (Author), Laszlo Prokai (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide. A representative prodrug based...