Dynamic Monitoring of Intracellular Tacrolimus and Mycophenolic Acid Therapy in Renal Transplant Recipients Using Magnetic Bead Extraction Combined with LC-MS/MS

• Main Authors: Huan Xu (Author), Yingying Liu (Author), Yinan Zhang (Author), Xinhua Dai (Author), Xueqiao Wang (Author), Haojun Chen (Author), Lin Yan (Author), Xingxin Gong (Author), Jiaxi Yue (Author), Zhengli Wan (Author), Jiwen Fan (Author), Yangjuan Bai (Author), Yao Luo (Author), Yi Li (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Tacrolimus (TAC) and mycophenolic acid (MPA) are commonly used immunosuppressive therapies after renal transplant. Our objective was to quantify TAC and MPA concentrations in peripheral blood mononuclear cells (PBMCs) using liquid chromatography tandem mass spectrometry (LC-MS/MS) and to...