Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary

• Main Authors: Nana Akino (Author), Osamu Wada-Hiraike (Author), Wataru Isono (Author), Hiromi Terao (Author), Harunori Honjo (Author), Yuichiro Miyamoto (Author), Michihiro Tanikawa (Author), Kenbun Sone (Author), Mana Hirano (Author), Miyuki Harada (Author), Tetsuya Hirata (Author), Yasushi Hirota (Author), Kaori Koga (Author), Katsutoshi Oda (Author), Tomoyuki Fujii (Author), Yutaka Osuga (Author)
• Format: Book
• Published: BMC, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Age-associated infertility is a problem worldwide, and management of oxidative stress is known to be essential. Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant response element (ARE) signaling pathway works as an essential defense...