Denervation atrophy is independent from Akt and mTOR activation and is not rescued by myostatin inhibition

• Main Authors: Elizabeth M. MacDonald (Author), Eva Andres-Mateos (Author), Rebeca Mejias (Author), Jessica L. Simmers (Author), Ruifa Mi (Author), Jae-Sung Park (Author), Stephanie Ying (Author), Ahmet Hoke (Author), Se-Jin Lee (Author), Ronald D. Cohn (Author)
• Format: Book
• Published: The Company of Biologists, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of our study was to compare two acquired muscle atrophies and the use of myostatin inhibition for their treatment. Myostatin naturally inhibits skeletal muscle growth by binding to ActRIIB, a receptor on the cell surface of myofibers. Because blocking myostatin in an adult wild-type mous...