Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming

• Main Authors: Dayuan Wang (Author), Xiao Gu (Author), Xinyi Ma (Author), Jun Chen (Author), Qizhi Zhang (Author), Zhihua Yu (Author), Juan Li (Author), Meng Hu (Author), Xiaofang Tan (Author), Yuyun Tang (Author), Jianrong Xu (Author), Minjun Xu (Author), Qingxiang Song (Author), Huahua Song (Author), Gan Jiang (Author), Zaiming Tang (Author), Xiaoling Gao (Author), Hongzhuan Chen (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta, tau, and α-synuclein aggregates in neurodegenerative diseases. However, due to the complex structure and ambiguous pathogenic species of the misfolded proteins, a universal approach to remove the mis...